Int J Biochem Mol Biol 2011;2(4):303-308
Original Article
RNAi-mediated knockdown of α-enolase increases the sensitivity of tumor cells to
antitubulin chemotherapeutics
Elias Georges, Anne-Marie Bonneau, Panagiotis Prinos
Institute of Parasitology, McGill University, Montreal, Quebec, Canada
Received September 10, 2011; accepted September 20, 2011; Epub October 21, 2011; Published December 15, 2011
Abstract: The over-expression of α-enolase was demonstrated in several cancers, including lung, brain, breast, colon and prostate. In this
report, we investigated the effects of α-enolase knockdown on the sensitivity of cancer cells to chemotherapeutic drugs. RNAi-mediated
knockdown of α-enolase in A549 and H460 lung, MCF7 breast and CaOV3 ovarian cancer cells caused a significant increase in the sensitivity
of these cells to antitubulin chemotherapeutics (e.g., vincristine and taxol), but not to doxorubicin, etoposide or cisplatinum. This is the first
demonstration showing the effects of α-enolase expression on the sensitivity of tumor cells to clinically relevant chemotherapeutics.
(IJBMB1109001)
Keywords: α-enolase, knockdown, chemotherapeutic drugs, antitubulin chemotherapeutics, sensitivity, cancer, RNAi,
A549, H460 lung, MCF7 breast, CaOV3
Full Text PDF
Address all correspondence to:
Dr. Elias Georges
Institute of Parasitology, McGill University
21,111 Lakeshore Road, Ste Anne-de Bellevue
Quebec, Canada, H9X 1C0
Phone (514) 398-8137. Fax: (514) 398-7857.
Email: elias.georges@McGill.com
Original Article
RNAi-mediated knockdown of α-enolase increases the sensitivity of tumor cells to
antitubulin chemotherapeutics
Elias Georges, Anne-Marie Bonneau, Panagiotis Prinos
Institute of Parasitology, McGill University, Montreal, Quebec, Canada
Received September 10, 2011; accepted September 20, 2011; Epub October 21, 2011; Published December 15, 2011
Abstract: The over-expression of α-enolase was demonstrated in several cancers, including lung, brain, breast, colon and prostate. In this
report, we investigated the effects of α-enolase knockdown on the sensitivity of cancer cells to chemotherapeutic drugs. RNAi-mediated
knockdown of α-enolase in A549 and H460 lung, MCF7 breast and CaOV3 ovarian cancer cells caused a significant increase in the sensitivity
of these cells to antitubulin chemotherapeutics (e.g., vincristine and taxol), but not to doxorubicin, etoposide or cisplatinum. This is the first
demonstration showing the effects of α-enolase expression on the sensitivity of tumor cells to clinically relevant chemotherapeutics.
(IJBMB1109001)
Keywords: α-enolase, knockdown, chemotherapeutic drugs, antitubulin chemotherapeutics, sensitivity, cancer, RNAi,
A549, H460 lung, MCF7 breast, CaOV3
Full Text PDF
Address all correspondence to:
Dr. Elias Georges
Institute of Parasitology, McGill University
21,111 Lakeshore Road, Ste Anne-de Bellevue
Quebec, Canada, H9X 1C0
Phone (514) 398-8137. Fax: (514) 398-7857.
Email: elias.georges@McGill.com
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